The metabolism of 2-carbon compounds related to glycine. I. Glyoxylic acid.

نویسندگان

  • A WEISSBACH
  • D B SPRINSON
چکیده

In a continuation of the search for intermediates involved in the condensation of the a-carbon atoms of 2 glycine molecules (l), investigations were carried out with ethanolamine-l-C13,2-C14 (C13H20H-C14H2NH2). It was considered possible that the serine synthesized from administered glycine2-Cl4 is, at first, labeled only in the a-carbon atom, the P-carbon atom being derived from unlabeled, endogenous sources of “formate.” If the ethanolamine formed from this serine (2) were capable of yielding a labeled lcarbon fragment, cr,/3-labeled serine would be produced. The results described below failed to support such a reaction scheme. It was shown, however, that a major reaction in the metabolism of ethanolamine is deamination, oxidation, and reamination to glycine.

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عنوان ژورنال:
  • The Journal of biological chemistry

دوره 203 2  شماره 

صفحات  -

تاریخ انتشار 1953